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Synthese De La Beta-naphtoflavone 14C-4 OU 14C-5 A Partir De L'Acide Phenylpropiolique (CARBOXYLE14C) Ou Du β-Naphtol 14C-8

✍ Scribed by Nguyen-Hoang Nam; Do-Cao Thang; P. Queval; L. Pichat

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
235 KB
Volume
17
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Carbonation with ^14^CO~2~ of penylethynyl‐lithium has given rise to (carboxyl‐^14^C) phenylpropiolic acid with 75 % yield based on ^14^CO^2^. The latter condensed with 2‐naphthol by treating with polyphosphoric acid afforded (4‐^14^C) β‐naphthoflavone, purified by silicagel low pressure liquid chromatography; 22 % overall yield based on ^14^CO~2~, SA = 13 mCi/mM. Similar run of 2‐(8‐^14^C) naphthol with phenylpropiolic acid gave (5‐ ^14^C) β‐naphthoflavone; 28 % yield based on radioactive 2‐naphthol, SA = 7.2 mCi/mM.

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