Synergistic induction of the differentiation of WEHI-3B D+ myelomonocytic leukemia cells by retinoic acid and granulocyte colony-stimulating factor
β Scribed by Jianming Li; Alan C. Sartorelli
- Book ID
- 113239550
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 615 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0145-2126
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π SIMILAR VOLUMES
It has been reported previously that cells of the murine myelomonocytic leukaemia cell line WEH13B(D+) can be induced to differentiate into mature monocytes by incubation with post-endotoxin serum (ES), granulocyte-colony-stimulating factor (G-CSF) or actinomycin D (AMD). We have investigated the ki
All-trans retinoic acid (ATRA) induces granulocytic maturation of WEHI-3B D+ leukemia cells and LiCl enhances this maturation, while WEHI-3B D- cells are non-responsive to ATRA. Transfection of SCL, expressed in D- but absent in D+ cells, into D+ cells, caused resistance to ATRA, while transfection