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Susceptibility effects in hyperpolarized 3He lung MRI at 1.5T and 3T

✍ Scribed by Martin H. Deppe; Juan Parra-Robles; Salma Ajraoui; Steven R. Parnell; Matthew Clemence; Rolf F. Schulte; Jim M. Wild

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
680 KB
Volume
30
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To compare susceptibility effects in hyperpolarized ^3^He lung MRI at the clinically relevant field strengths of 1.5T and 3T.

Materials and Methods

Susceptibility‐related B~0~ inhomogeneity was evaluated on a macroscopic scale by B~0~ field mapping via phase difference. Subpixel susceptibility effects were quantified by mapping T. Comparison was made between ventilation images obtained from the same volunteers at both field strengths.

Results

The B~0~ maps at 3T show enhanced off‐resonance effects close to the diaphragm and the ribs due to susceptibility differences. The average T from a voxel (20 × 4 × 4) mm^3^ was determined as T = 27.8 msec ± 1.2 msec at 1.5T compared to T = 14.4 msec ± 2.6 msec at 3T. In ventilation images the most prominent effect is increased signal attenuation close to the intrapulmonary blood vessels at higher B~0~.

Conclusion

Image homogeneity and T are lower at 3T due to increased B~0~ inhomogeneity as a consequence of susceptibility differences. These findings indicate that ^3^He imaging at 3T has no obvious benefit over imaging at 1.5T, as signal‐to‐noise ratio (SNR) was comparable for both fields in this work. J. Magn. Reson. Imaging 2009;30:418–423. © 2009 Wiley‐Liss, Inc.

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