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Imaging lung microstructure in mice with hyperpolarized 3He diffusion MRI

✍ Scribed by Wei Wang; Nguyet M. Nguyen; Dmitriy A. Yablonskiy; Alexander L. Sukstanskii; Emir Osmanagic; Jeffrey J. Atkinson; Mark S. Conradi; Jason C. Woods

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
328 KB
Volume
65
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Quantitative measurement of lung microstructure is of great significance in assessment of pulmonary disease, particularly in the earliest stages. The technique for MRI‐based ^3^He lung morphometry was previously developed and validated for human lungs, and was recently extended to ex vivo mouse lungs. The technique yields accurate, quantitative information about the microstructure and geometry of acinar airways. In this study, the ^3^He lung morphometry technique is successfully implemented for in vivo studies of mice. Results indicate excellent agreement between in vivo morphometry via ^3^He MRI and microscopic morphometry after sacrifice. This opens up new avenues for application of the technique as a precise, noninvasive, in vivo biomarker of changes in lung microstructure, within various mouse models of lung disease. Magn Reson Med, 2011. © 2010 Wiley‐Liss, Inc.

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