## Abstract Quantitative measurement of lung microstructure is of great significance in assessment of pulmonary disease, particularly in the earliest stages. The technique for MRI‐based ^3^He lung morphometry was previously developed and validated for human lungs, and was recently extended to ex vi
Diffusion Imaging with Hyperpolarized3He Gas
✍ Scribed by David M. Schmidt; John S. George; Seppo I. Penttila; Arvind Caprihan; Eiichi Fukushima
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 189 KB
- Volume
- 129
- Category
- Article
- ISSN
- 1090-7807
No coin nor oath required. For personal study only.
✦ Synopsis
We used MRI of hyperpolarized 3He to demonstrate some novel aspects of gas diffusion. Two different techniques were used. First, a slice was burned into a one-dimensional image by inverting the spins in the slice and diffusion was studied by measuring the magnetization as it filled the depleted slice. A diffusion coefficient was determined by the fit of these data. Second, one-dimensional diffusion images were made using a Stejskal-Tanner PGSE method. This was done with and without a temperature gradient present, showing that the effect of temperature can be dynamically monitored by such diffusion images. Copyright 1997 Academic Press. Copyright 1997Academic Press
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