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Long-range diffusion of hyperpolarized 3He in rats

✍ Scribed by Ignacio Rodríguez; José Manuel Pérez-Sánchez; Germán Peces-Barba; Thomas Kaulisch; Detlef Stiller; Jesús Ruiz-Cabello

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
347 KB
Volume
61
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Based on a stimulated‐echo technique, a method to construct an apparent diffusion coefficient (ADC) map of hyperpolarized ^3^He in a long‐range diffusion scale is presented with a phase‐cycle alternative to remove all unwanted echoes. The approach was successfully applied to determine in vivo diffusion constants in rat lungs. The ADC values in healthy rats show a good agreement with reported values for diffusion times of ≈. These long diffusivity measurements may be sensitive to detect emphysema progression or tissue remodeling and thus have enormous potential for the diagnosis and tracking of disease progression and for drug evaluation. Magn Reson Med 61:54–58, 2009. © 2008 Wiley‐Liss, Inc.

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