Hyperpolarized 3He lung imaging at 0.5 and 1.5 Tesla: A study of susceptibility-induced effects

✍ Scribed by Michael Salerno; James R. Brookeman; Eduard E. de Lange; John P. Mugler III

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 588 KB
• Volume: 53
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.20329

✦ Synopsis

Abstract

Hyperpolarized ^3^He MRI of the human lung was performed at 0.54 and 1.5 T using identical software and hardware (except for RF coils) at both field strengths. The T of ^3^He gas in the lung was measured, and the effects of magnetic‐susceptibility‐induced field inhomogeneities on the appearance of interleaved‐spiral and interleaved‐echo‐planar lung images at 1.5 T were compared to those at 0.54 T. Mean T values for ^3^He gas in the healthy human lung were 26.8 ± 1.5 ms and 67.9 ± 1.3 ms at 1.5 and 0.54 T, respectively. At 0.54 T, interleaved‐spiral images showed markedly less blurring due to susceptibility effects compared to images acquired at 1.5 T. At both 0.54 and 1.5 T, interleaved‐echo‐planar images appeared essentially identical to corresponding GRE images, even though the data‐sampling period per echo and echo time were substantially longer for the interleaved‐echo‐planar images acquired at 0.54 T. Magn Reson Med 53:212–216, 2005. © 2004 Wiley‐Liss, Inc.