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Survey of the year 2005: literature on applications of isothermal titration calorimetry

✍ Scribed by Adessamad Ababou; John E. Ladbury

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
241 KB
Volume
20
Category
Article
ISSN
0952-3499

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✦ Synopsis

Abstract

Isothermal titration calorimetry (ITC) can provide a full thermodynamic characterization of an interaction. Its usage does not suffer from constraints of molecular size, shape or chemical constitution. Neither is there any need for chemical modification or attachment to solid support. This ease of use has made it an invaluable instrumental resource and led to its appearance in many laboratories. Despite this, the value of the thermodynamic parameterization has, only quite recently, become widely appreciated. Although our understanding of the correlation between thermodynamic data and structural details continues to be somewhat naΓ―ve, a large number of publications have begun to improve the situation. In this overview of the literature for 2005, we have attempted to highlight works of interest and novelty. Furthermore, we draw attention to those works which we feel have provided a route to better analysis and increased our ability to understand the meaning of thermodynamic change on binding. Copyright Β© 2006 John Wiley & Sons, Ltd.

πŸ“œ SIMILAR VOLUMES

Survey of the year 2004: literature on a
Survey of the year 2004: literature on applications of isothermal titration calorimetry
✍ Abdessamad Ababou; John E. Ladbury πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 243 KB

## Abstract The market for commercially available isothermal titration calorimeters continues to grow as new applications and methodologies are developed. Concomitantly the number of users (and abusers) increases dramatically, resulting in a steady increase in the number of publications in which is

A survey of the year 2002 literature on
A survey of the year 2002 literature on applications of isothermal titration calorimetry
✍ Matthew J. Cliff; John E. Ladbury πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 125 KB

## Abstract Isothermal titration calorimetry (ITC) is becoming widely accepted as a key instrument in any laboratory in which quantification of biomolecular interactions is a requisite. The method has matured with respect to general acceptance and application development over recent years. The numb

A survey of the year 2003 literature on
A survey of the year 2003 literature on applications of isothermal titration calorimetry
✍ Matthew J. Cliff; Aldo Gutierrez; John E. Ladbury πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 186 KB

## Abstract Over the last decade isothermal titration calorimetry (ITC) has developed from a specialist method which was largely restricted in its use to dedicated experts, to a major, commercially available tool in the arsenal directed at understanding molecular interactions. The number of those p

Survey of the year 2009: applications of
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✍ Robert J. Falconer; Brett M. Collins πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 281 KB

Isothermal titration calorimetry (ITC) is now an established and invaluable method for determining the thermodynamic constants, association constant and stoichiometry of molecular interactions in aqueous solutions. The technique has become widely used by biochemists to study protein interaction with