## Abstract The market for commercially available isothermal titration calorimeters continues to grow as new applications and methodologies are developed. Concomitantly the number of users (and abusers) increases dramatically, resulting in a steady increase in the number of publications in which is
A survey of the year 2003 literature on applications of isothermal titration calorimetry
β Scribed by Matthew J. Cliff; Aldo Gutierrez; John E. Ladbury
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 186 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0952-3499
- DOI
- 10.1002/jmr.714
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β¦ Synopsis
Abstract
Over the last decade isothermal titration calorimetry (ITC) has developed from a specialist method which was largely restricted in its use to dedicated experts, to a major, commercially available tool in the arsenal directed at understanding molecular interactions. The number of those proficient in this field has multiplied dramatically, as has the range of experiments to which this method has been applied. This has led to an overwhelming amount of new data and novel applications to be assessed. With the increasing number of publications in this field comes a need to highlight works of interest and impact. In this overview of the literature we have attempted to draw attention to papers and issues for which both the experienced calorimetrist and the interested dilettante hopefully will share our enthusiasm. Copyright Β© 2004 John Wiley & Sons, Ltd.
π SIMILAR VOLUMES
## Abstract Isothermal titration calorimetry (ITC) can provide a full thermodynamic characterization of an interaction. Its usage does not suffer from constraints of molecular size, shape or chemical constitution. Neither is there any need for chemical modification or attachment to solid support. T
## Abstract Isothermal titration calorimetry (ITC) is becoming widely accepted as a key instrument in any laboratory in which quantification of biomolecular interactions is a requisite. The method has matured with respect to general acceptance and application development over recent years. The numb
Isothermal titration calorimetry (ITC) is now an established and invaluable method for determining the thermodynamic constants, association constant and stoichiometry of molecular interactions in aqueous solutions. The technique has become widely used by biochemists to study protein interaction with
## Abstract Understanding the nature of binding of polycationic dendrimers to DNA provides useful information on their role in gene delivery. In the present study, we have characterized the interaction of several peptideβbased polycationic dendrimers with salmon sperm DNA using isothermal titration