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Suramin disrupts insulin-like growth factor-II (IGF-II) mediated autocrine growth in human SH-SY5Y neuroblastoma cells

✍ Scribed by Kelli A. Sullivan; Bhumsoo Kim; Molly Buzdon; Eva L. Feldman

Book ID
114001994
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
357 KB
Volume
744
Category
Article
ISSN
0006-8993

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## Insulin -like growth factors (IGFs) are potent proliferation stimulators for numerous tumor cells and often function as autocrine growth factors. We have previously shown that exogenous IGF-I and IGF-II enhance proliferation of colorectal carcinoma cells. The biological signal of both factors i