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Human neuroblastoma cells use either insulin-like growth factor-I or insulin-like growth factor-II in an autocrine pathway via the IGF-I receptor: Variability of IGF, IGF binding protein (IGFBP) and IGF receptor gene expression and IGF and IGFBP secretion in human neuroblastoma cells in relation to cellular proliferation

✍ Scribed by Wieland Kiess; Gabriele Koepf; Holger Christiansen; Werner F Blum


Book ID
117349326
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
1002 KB
Volume
72
Category
Article
ISSN
0167-0115

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Osteogenic protein-1 (OP-1 or BMP-7) stimulates new bone formation in vivo and induces cell proliferation and differentiation of osteoblasts in vitro. Previous studies from our laboratory revealed that OP-1 led to a two-to threefold increase in steady-state insulin-like growth factor-I (IGF-I) and I