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Evidence against a direct effect of leptin on insulin-like growth factor-I (IGF-I), IGFBP-2 and IGF-I receptor expression in human SK-N-MC neuroepithelioma cells

✍ Scribed by Wieland Kiess; Jürgen Klammt; Jörg Hänze; Werner F. Blum; Antje Berthold; Bertolt Seidel; Jürgen Kratzsch


Book ID
116857721
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
268 KB
Volume
130
Category
Article
ISSN
0167-0115

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## Abstract We examined the relationship between signal transduction and the expression of insulin‐like growth factor I (IGF‐I), IGF‐I receptor level, and IGF binding proteins (IGFBPs) in murine clonal osteoblastic MC3T3‐E1 cells. 12–O‐Tetradecanoylphorbol‐13‐acetate (TPA), an activator of protein