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Inhibition of insulin like growth factor II autocrine growth of Wilms' tumor by suramin in vitro and in vivo

โœ Scribed by Timothy S. Vincent; Debra J. Hazen-Martin; A.Julian Garvin


Book ID
116123485
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
780 KB
Volume
103
Category
Article
ISSN
0304-3835

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In this study messenger ribonucleic acid (mRNA) and DNA of five Wilms tumours were investigated. As expected, the level of insulin-like growth factor (IGF) II-mRNA was elevated up to 50 times in tumour tissue as compared to normal adjacent kidney tissue. In addition, genomic DNA was isolated and dig