𝔖 Bobbio Scriptorium
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Supports for the solid-phase synthesis of oligonucleotides with a 5′-terminal phosphate group

✍ Scribed by Yu. V. Tumanov; V. K. Potapov; Z. A. Shabarova

Book ID
112372334
Publisher
Springer
Year
1978
Tongue
English
Weight
468 KB
Volume
14
Category
Article
ISSN
0009-3130

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Michaelis-Arbusov chemistry was used to prepare O,S-dialkyl Y-O-nucleosidyl phosphorothiolate triesters in solution and attached to CPG. The support-bound nucleoside was utilised in the synthesis of a pentaribonucleotide that was fully deprotected on the support. Subsequent ~'eatment with a buffere