Michaelis-Arbusov chemistry was used to prepare O,S-dialkyl Y-O-nucleosidyl phosphorothiolate triesters in solution and attached to CPG. The support-bound nucleoside was utilised in the synthesis of a pentaribonucleotide that was fully deprotected on the support. Subsequent ~'eatment with a buffere
A new solid phase approach for rapid syntheses of oligonucleotides bearing a 3′-terminal phosphate group
✍ Scribed by Eduard Felder; Robert Schwyzer; Ramamurthy Charubala; Wolfgang Pfleiderer; Bernd Schulz
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 259 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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