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A new approach for the synthesis of 3′-deoxy-3′-C-formyl-ribonucleosides and the synthesis of alternating methylene(methylimino) linked phosphodiester backbone oligonucleotides with 2′-OH and 2′-OMe groups

✍ Scribed by Marija Prhavc; George Just*; Balkrishen Bhat; P.Dan Cook; Muthiah Manoharan

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 94 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01814-1

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✦ Synopsis

A stereoselective synthesis of 3%-deoxy-3%-C-formyl-5-methyluridine 2 is described via the dithiane 4 as the key intermediate. Compound 2 was coupled with 3 into a novel ribo-MMI dimer 1. The dimer was then incorporated into antisense oligonucleotides which were found to have high binding affinity to the target RNA.

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ChemInform Abstract: A New Approach for

ChemInform Abstract: A New Approach for the Synthesis of 3′-Deoxy-3′-C-formyl-ribonucleosides and the Synthesis of Alternating Methylene(methylimino) Linked Phosphodiester Backbone Oligonucleotides with 2′-OH and 2′-OMe Groups.

✍ Marija Prhavc; George Just; Balkrishen Bhat; P. Dan Cook; Muthiah Manoharan 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 34 KB 👁 2 views