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Sulindac and sulindac sulfide reduce the level and activity of cyclin dependent kinases and induce apoptosis in HT-29 colon adenocarcinoma cells

✍ Scribed by S.J. Shill; L. Qiao; L.-L. Tsai; B. Rigas


Book ID
118880150
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
155 KB
Volume
108
Category
Article
ISSN
0016-5085

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✍ Liang Qiao; Steven J. Shiff; Basil Rigas πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 French βš– 152 KB

Sulindac sulfide (SS), the active metabolite of the colon cancer chemopreventive compound sulindac, inhibits the proliferation of HT-29 colon cancer cells mainly by inducing cell quiescence. We determined by bivariate flow-cytometric analysis both the DNA and cyclin protein content of individual cel