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Effects of sulindac, sulindac metabolites, and aspirin on the activity of detoxification enzymes in HT-29 human colon adenocarcinoma cells

✍ Scribed by Emma J Patten; Mary J DeLong


Book ID
117469639
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
149 KB
Volume
147
Category
Article
ISSN
0304-3835

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Sulindac sulfide alters the expression o
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Sulindac sulfide (SS), the active metabolite of the colon cancer chemopreventive compound sulindac, inhibits the proliferation of HT-29 colon cancer cells mainly by inducing cell quiescence. We determined by bivariate flow-cytometric analysis both the DNA and cyclin protein content of individual cel