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Effect of Sulindac Sulfide on Metallohydrolases in the Human Colon Cancer Cell Line HT-29

✍ Scribed by Guillen-Ahlers, Hector; Tan, Jiangning; Castellino, Francis J.; Ploplis, Victoria A.; Bogyo, Matthew


Book ID
120179324
Publisher
Public Library of Science
Year
2011
Tongue
English
Weight
374 KB
Volume
6
Category
Article
ISSN
1932-6203

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Sulindac sulfide (SS), the active metabolite of the colon cancer chemopreventive compound sulindac, inhibits the proliferation of HT-29 colon cancer cells mainly by inducing cell quiescence. We determined by bivariate flow-cytometric analysis both the DNA and cyclin protein content of individual cel