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Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor

✍ Scribed by M. Raymond V. Finlay; David Buttar; Susan E. Critchlow; Allan P. Dishington; Shaun M. Fillery; Eric Fisher; Steve C. Glossop; Mark A. Graham; Trevor Johnson; Gillian M. Lamont; Simon Mutton; Paula Perkins; Kurt G. Pike; Anthony M. Slater.


Book ID
113496863
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
844 KB
Volume
22
Category
Article
ISSN
0960-894X

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Phenylamino-Pyrimidine (PAP) Derivatives
✍ JΓΌrg Zimmermann; Giorgio Caravatti; Helmut Mett; Thomas Meyer; Marcel MΓΌller; Ni πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 589 KB

Phenylamino-pyrimidines represent a novel class of inhibitors of the protein kinase C with a high degree of selectivity versus other serindthreonine and tyrosine kinases. Steady state kinetic analysis of N-(3-[ 1 -imidazolyl]-phenyl)-4-(3-pyridyl)-2-pyrimidinamine (3, which showed potent inhibitory