Receptor tyrosine kinases (RTKs) are important mediators of signal transduction and play critical roles in cell growth, differentiation, metabolism, and apoptosis, and are deeply involved in oncogenesis. Binding of growth factors to the extracellular domains of RTKs leads to their dimerization, resu
โฆ LIBER โฆ
The Synthesis and SAR of 2-Amino-pyrrolo[2,3-d]pyrimidines: A New Class of Aurora-A Kinase Inhibitors.
โ Scribed by Kevin J. Moriarty; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 12 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Three previously undescribed dihydrofolate reductase (DHFR) inhibitors, N^ฮฑ^โ[4โ[__N__โ[(2,4โdiaminopyrrolo[2,3โ__d__]pyrimidinโ5โyl)methyl]amino]benzoyl]โ__N__^ฮด^โhemiphthaloylโLโornithine **(7)**, __N__^ฮฑ^โ [4โ [__N__โ[(2,4โdiaminothieno[2,3โ__d__]pyrimidinโ5โyl)methyl]amino]benzoyl]โ
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