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VS-5584, a Novel and Highly Selective PI3K/mTOR Kinase Inhibitor for the Treatment of Cancer

✍ Scribed by Hart, S.; Novotny-Diermayr, V.; Goh, K. C.; Williams, M.; Tan, Y. C.; Ong, L. C.; Cheong, A.; Ng, B. K.; Amalini, C.; Madan, B.; Nagaraj, H.; Jayaraman, R.; Pasha, K. M.; Ethirajulu, K.; Chng, W. J.; Mustafa, N.; Goh, B. C.; Benes, C.; McDermott, U.; Garnett, M.; Dymock, B.; Wood, J. M.


Book ID
118229301
Publisher
American Association for Cancer Research
Year
2012
Tongue
English
Weight
971 KB
Volume
12
Category
Article
ISSN
1535-7163

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The efficacy of a novel, dual PI3K/mTOR
✍ Niranjan Awasthi; Peter L. Yen; Margaret A. Schwarz; Roderich E. Schwarz πŸ“‚ Article πŸ“… 2012 πŸ› John Wiley and Sons 🌐 English βš– 419 KB

## Abstract Gemcitabine has limited clinical benefits for pancreatic ductal adenocarcinoma (PDAC). The phosphatidylinositol‐3‐kinase (PI3K)/AKT and mammalian target of rapamycin (mTOR) signaling pathways are frequently dysregulated in PDAC. We investigated the effects of NVP‐BEZ235, a novel dual PI