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ChemInform Abstract: Phenylamino-pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC)

✍ Scribed by J. ZIMMERMANN; G. CARAVATTI; H. METT; T. MEYER; M. MUELLER; N. B. LYDON; D. FABBRO


Book ID
112040166
Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
27
Category
Article
ISSN
0931-7597

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Phenylamino-Pyrimidine (PAP) Derivatives
✍ JΓΌrg Zimmermann; Giorgio Caravatti; Helmut Mett; Thomas Meyer; Marcel MΓΌller; Ni πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 589 KB

Phenylamino-pyrimidines represent a novel class of inhibitors of the protein kinase C with a high degree of selectivity versus other serindthreonine and tyrosine kinases. Steady state kinetic analysis of N-(3-[ 1 -imidazolyl]-phenyl)-4-(3-pyridyl)-2-pyrimidinamine (3, which showed potent inhibitory