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Phenylamino-pyrimidine (PAP) — derivatives: a new class of potent and highly selective PDGF-receptor autophosphorylation inhibitors

✍ Scribed by Jürg Zimmermann; Elisabeth Buchdunger; Helmut Mett; Thomas Meyer; Nicholas B. Lydon; Peter Traxler


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
316 KB
Volume
6
Category
Article
ISSN
0960-894X

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Phenylamino-Pyrimidine (PAP) Derivatives
✍ Jürg Zimmermann; Giorgio Caravatti; Helmut Mett; Thomas Meyer; Marcel Müller; Ni 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 589 KB

Phenylamino-pyrimidines represent a novel class of inhibitors of the protein kinase C with a high degree of selectivity versus other serindthreonine and tyrosine kinases. Steady state kinetic analysis of N-(3-[ 1 -imidazolyl]-phenyl)-4-(3-pyridyl)-2-pyrimidinamine (3, which showed potent inhibitory