๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Sulfobetaine zwitterionic inhibitors of squalene synthase

โœ Scribed by Ishaiahu Shechter; Peide Gu; Guojian Jiang; Thomas J. Onofrey; Reginald O. Cann; Alfredo Castro; Thomas A. Spencer


Book ID
103983599
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
176 KB
Volume
6
Category
Article
ISSN
0960-894X

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Squalene synthase inhibitors
โœ Andrew W. Lloyd ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 112 KB
Squalene synthase inhibitors
โœ V C Menys; P N Durrington ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 83 KB
Squalene Synthase Inhibitors
โœ Dr Valentine Charlton-Menys, Paul N. Durrington ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Springer International Publishing AG ๐ŸŒ English โš– 90 KB
Novel optimised quinuclidine squalene sy
โœ George R. Brown; Alan J. Foubister; Susan Freeman; Fergus McTaggart; Donald J. M ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 221 KB

Optimised quinuclidine squalene synthase (SQS) inhibitors are reported; 3-[2-(2-allyl-4-(2-ethoxy carbonylethyl)phenyl)ethynyl]quinuclidin-3-ol lc, is a potent inhibitor of rat (KI = 6 nM) and human (KI = 43 nM) microsomal SQS; the oral EDso of lc, for the inhibition of rat cholesterol biosynthesis