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Squalene synthase inhibitors

โœ Scribed by V C Menys; P N Durrington


Book ID
110007866
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
83 KB
Volume
139
Category
Article
ISSN
0007-1188

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Optimised quinuclidine squalene synthase (SQS) inhibitors are reported; 3-[2-(2-allyl-4-(2-ethoxy carbonylethyl)phenyl)ethynyl]quinuclidin-3-ol lc, is a potent inhibitor of rat (KI = 6 nM) and human (KI = 43 nM) microsomal SQS; the oral EDso of lc, for the inhibition of rat cholesterol biosynthesis