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Squalene synthase inhibitors

โœ Scribed by Andrew W. Lloyd


Book ID
113411136
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
112 KB
Volume
1
Category
Article
ISSN
1359-6446

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Optimised quinuclidine squalene synthase (SQS) inhibitors are reported; 3-[2-(2-allyl-4-(2-ethoxy carbonylethyl)phenyl)ethynyl]quinuclidin-3-ol lc, is a potent inhibitor of rat (KI = 6 nM) and human (KI = 43 nM) microsomal SQS; the oral EDso of lc, for the inhibition of rat cholesterol biosynthesis