๐”– Bobbio Scriptorium
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Squalene Synthase Inhibitors

โœ Scribed by Dr Valentine Charlton-Menys, Paul N. Durrington


Book ID
119928688
Publisher
Springer International Publishing AG
Year
2007
Tongue
English
Weight
90 KB
Volume
67
Category
Article
ISSN
0012-6667

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Optimised quinuclidine squalene synthase (SQS) inhibitors are reported; 3-[2-(2-allyl-4-(2-ethoxy carbonylethyl)phenyl)ethynyl]quinuclidin-3-ol lc, is a potent inhibitor of rat (KI = 6 nM) and human (KI = 43 nM) microsomal SQS; the oral EDso of lc, for the inhibition of rat cholesterol biosynthesis