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Substrate-Dependent Ligand Inhibition of the Human Organic Cation Transporter OCT2

✍ Scribed by Belzer, M.; Morales, M.; Jagadish, B.; Mash, E. A.; Wright, S. H.

Book ID
121795925
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2013
Tongue
English
Weight
451 KB
Volume
346
Category
Article
ISSN
0022-3565

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The human organic cation transporter 2 (OCT2, SLC22A2) is a multispecific transporter of organic cations, including many clinically used drugs. OCT2 is primarily responsible for the uptake of organic cations across the basolateral membrane of renal tubular epithelial cells and is considered a major