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Transport of biguanides by human organic cation transporter OCT2

✍ Scribed by Sogame, Yoshihisa; Kitamura, Atsushi; Yabuki, Masashi; Komuro, Setsuko; Takano, Mikihisa

Book ID
123157833
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
650 KB
Volume
67
Category
Article
ISSN
0753-3322

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The human organic cation transporter 2 (OCT2, SLC22A2) is a multispecific transporter of organic cations, including many clinically used drugs. OCT2 is primarily responsible for the uptake of organic cations across the basolateral membrane of renal tubular epithelial cells and is considered a major