Structural determinants of inhibitor interaction with the human organic cation transporter OCT2 (SLC22A2)
✍ Scribed by Oliver Zolk; Thomas F. Solbach; Jörg König; Martin F. Fromm
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 425 KB
- Volume
- 379
- Category
- Article
- ISSN
- 0028-1298
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The human organic cation transporter 2 (OCT2, SLC22A2) is a multispecific transporter of organic cations, including many clinically used drugs. OCT2 is primarily responsible for the uptake of organic cations across the basolateral membrane of renal tubular epithelial cells and is considered a major
Secretion of small molecules from the systemic blood circulation into urine is one of the physiologically essential functions of the kidney. The human organic anion transporter (hOAT1) is a key component in the renal tubular secretion of negatively charged molecules including a variety of important