Substitution of cellular fatty acids in yeast cells by the antibiotic cerulenin and exogenous fatty acids
✍ Scribed by Juichi Awaya; Tadao Ohno; Hiroie Ohno; Satoshi Ōmura
- Book ID
- 115736967
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- English
- Weight
- 520 KB
- Volume
- 409
- Category
- Article
- ISSN
- 0005-2760
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## Abstract The growth response of a double‐mutant fatty acid auxotroph of yeast Saccharomyces cerevisiae to exogenous saturated fatty acids of a homologous series from 12:0 to 16:0, each supplied with oleate, linoleate, linolenate, or __cis__‐Δ^11^‐ eicosenoate, cannot be explained in terms of the
In relation to the mechanism of fatty acid synthetase inhibition by cerulenin (1) the reaction between this antibiotic and thiols were studied. The structures of the propanethiol adduct 2 and of the cysteine methyl ester adduct 3 were determined to be respective (2S, 3R)-2Ialkylmercapto-3-hydroxy de