Effect of exogenous fatty acids on growth, membrane fluidity, and phospholipid fatty acid composition in yeast

✍ Scribed by Esfahani, Mojtaba ;Kucirka, Elise M. ;Timmons, Frank X. ;Tyagi, Somdev ;Lord, Arthur E. ;Henry, Susan A.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1981
• Tongue: English
• Weight: 559 KB
• Volume: 15
• Category: Article
• ISSN: 0275-3723
• DOI: 10.1002/jsscb.1981.380150203

✦ Synopsis

Abstract

The growth response of a double‐mutant fatty acid auxotroph of yeast Saccharomyces cerevisiae to exogenous saturated fatty acids of a homologous series from 12:0 to 16:0, each supplied with oleate, linoleate, linolenate, or cis‐Δ^11^‐ eicosenoate, cannot be explained in terms of the efficiency of incorporation of the fatty acids into phospholipids or alteration of membrane fluidity. There is, however, a negative correlation between growth and levels of 12:0 plus 13:0 in phospholipids, as well as a positive correlation between growth and levels of 14:0, 1 5:0, and 1 6:0. We, therefore, conclude that the predominant factor in these phospholipid fatty acyl chain modifications is maintenance of an optimal concentration of C14:0 through C16:0 in phospholipids of this organism.