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Membrane fluidity and fatty acid composition of phospholipids in erythrocyte membranes of patients with huntington disease

✍ Scribed by Mary E. Abood; Madeline Butler

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 275 KB
Volume: 4
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490040305

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✦ Synopsis

A study war undertaken to determine whether. alterations in the configuration of erythrocyte rnenibrancs of patients with Huntington disease, reported by other investigators, could be reflected in membrane fluidity-viscosity. Sincc membrane fluidity appears to he related to the fatty acid composition of mcmbrdne phospholipids, these were also examined. Membrane fluidity. which was determined by measuring the intrinsic fluorescence of membranous tryptophan, was found to be normal. Although the range of fatty acid distribution within the various phospholipids tended to vary somewhat, the pattern was not significantly different from that of' the controls.

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