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Erythrocyte membrane alterations in Huntington disease: Effects of γ-aminobutyric acid

✍ Scribed by Butterfield, D. A. ;Braden, M. L. ;Markesbery, W. R.

Publisher
Wiley (John Wiley & Sons)
Year
1978
Tongue
English
Weight
373 KB
Volume
9
Category
Article
ISSN
0091-7419

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✦ Synopsis

Abstract

The interaction of the inhibitory neurotransmitter γ‐aminobutyric acid (GABA) with erythrocyte membranes from patients with Huntington disease and normal controls has been studied by electron spin resonance. GABA affects the physical state of erythrocyte membrane proteins in control and Huntington disease differently. In addition, after exposure of spin‐labeled Huntington disease erythrocyte membranes to 0.1 mM GABA, the relevant electron spin resonance parameters reflecting the physical state of membrane proteins are indistinguishable from those of untreated control membranes. These findings support the concept that this disease is associated with a generalized membrane defect.

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