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Inhibition of unsaturated fatty acid synthesis in Escherichia coli by the antibiotic cerulenin

✍ Scribed by Buttke, Thomas M.; Ingram, Lonnie O'Neal


Book ID
126916470
Publisher
American Chemical Society
Year
1978
Tongue
English
Weight
646 KB
Volume
17
Category
Article
ISSN
0006-2960

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In relation to the mechanism of fatty acid synthetase inhibition by cerulenin (1) the reaction between this antibiotic and thiols were studied. The structures of the propanethiol adduct 2 and of the cysteine methyl ester adduct 3 were determined to be respective (2S, 3R)-2Ialkylmercapto-3-hydroxy de