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Inhibition of fatty acid synthetases by the antibiotic cerulenin

✍ Scribed by D. Vance; I. Goldberg; O. Mitsuhashi; K. Bloch; Satoshi Ōmura; Setsuzō Nomura

Book ID
118853146
Publisher
Elsevier Science
Year
1972
Tongue
English
Weight
363 KB
Volume
48
Category
Article
ISSN
0006-291X

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A model study on the mechanism of fatty acid synthetase inhibition by antibiotic cerulenin
✍ Hiroshi Funabashi; Shigeo Iwasaki; Shigenobu Okuda; Satoshi Ōmura 📂 Article 📅 1983 🏛 Elsevier Science 🌐 French ⚖ 215 KB

In relation to the mechanism of fatty acid synthetase inhibition by cerulenin (1) the reaction between this antibiotic and thiols were studied. The structures of the propanethiol adduct 2 and of the cysteine methyl ester adduct 3 were determined to be respective (2S, 3R)-2Ialkylmercapto-3-hydroxy de