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Growth inhibition of Halobacterium cutirubrum by cerulenin, a potent inhibitor of fatty acid synthesis

✍ Scribed by Craig Dees; James D. Oliver


Book ID
118311814
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
396 KB
Volume
78
Category
Article
ISSN
0006-291X

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In relation to the mechanism of fatty acid synthetase inhibition by cerulenin (1) the reaction between this antibiotic and thiols were studied. The structures of the propanethiol adduct 2 and of the cysteine methyl ester adduct 3 were determined to be respective (2S, 3R)-2Ialkylmercapto-3-hydroxy de