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Substance P analogues function as bombesin receptor antagonists and inhibit small cell lung cancer clonal growth

โœ Scribed by Bepler, Gerold; Zeymer, Uwe; Mahmoud, Samira; Fiskum, Gary; Palaszynski, Edmund; Rotsch, Martin; Willey, James; Koros, Aurelia; Cuttitta, Frank; Moody, Terry W.

Book ID
123198316
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
558 KB
Volume
9
Category
Article
ISSN
0196-9781

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(D-Phe12) bombesin and substance P analo
(D-Phe12) bombesin and substance P analogues function as central bombesin receptor antagonists
โœ Zul Merali; Carol A. Merchant; Jacqueline N. Crawley; David H. Coy; Peter Heinz- ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 676 KB

The potency of synthetic bombesin (BN) analogues with D-Phe12 substitutions and substance P analogues was investigated in the rat CNS. (D-Phe12,Leu14)BN, (D-Phe12)BN and (Tyr4,D-Phe12)BN inhibited binding to rat brain slices with IC50 values of approximately 2 microM. Similarly, spantide inhibited b