## BACKGROUND. Antagonists of bombesin/gastrin-releasing peptide (BN/GRP) have been developed to block the autocrine stimulatory effect of BN/GRP on tumors such as small cell lung carcinoma (SCLC). Although several studies have addressed the intracellular events that follow the formation of the re
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Reduction in Receptors for Bombesin and Epidermal Growth Factor in Xenografts of Human Small-Cell Lung Cancer after Treatment with Bombesin Antagonist RC-3095
โ Scribed by Gabor Halmos and Andrew V. Schally
- Book ID
- 123640421
- Publisher
- National Academy of Sciences
- Year
- 1997
- Tongue
- English
- Weight
- 844 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/41417
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## Abstract Nude mice bearing xenografts of the gastrinโresponsive human gastric carcinoma MKN45 cell line were treated for 4 to 5 weeks with bombesin/gastrinโreleasingโpeptide(GRP) antagonist (RCโ3095), somatostatin analogues RCโ160 and SMS 201โ995, or the combination of RCโ3095 and RCโ160. Tumor
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