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Antagonists of growth hormone releasing hormone and bombesin inhibit the expression of EGF/HER receptor family in H-69 small cell lung carcinoma

✍ Scribed by Celia A. Kanashiro; Andrew V. Schally; Jozsef L. Varga; Brian Hammann; Gabor Halmos; Marta Zarandi

Book ID
116333578
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
169 KB
Volume
226
Category
Article
ISSN
0304-3835

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## Abstract We investigated the effects of antagonists of growth hormone‐releasing hormone (GHRH) alone and in combination with bombesin/gastrin‐releasing peptide (BN/GRP) antagonist RC‐3940‐II on the growth of H‐69 human small cell lung carcinoma (SCLC) xenografted into nude mice. Since the activa

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## BACKGROUND. Antagonists of bombesin/gastrin-releasing peptide (BN/GRP) have been developed to block the autocrine stimulatory effect of BN/GRP on tumors such as small cell lung carcinoma (SCLC). Although several studies have addressed the intracellular events that follow the formation of the re