## Background: Hormones like bombesin (bn)/gastrin-releasing peptide (grp) and luteinizing hormone-releasing hormone (lh-rh) and growth factors such as epidermal growth factor (egf) might be involved in the relapse of prostate cancer under androgen ablation therapy. interference with receptors for
✦ LIBER ✦
Luteinizing hormone–releasing hormone (LH–RH) antagonist Cetrorelix inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels and mRNA expression of IGF-II in tumors
✍ Scribed by Najib Lamharzi; Andrew V Schally; Miklós Koppán
- Book ID
- 117349477
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 284 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0167-0115
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Experiments have been performed to clarify whether LHRH agonists might decrease growth of hormone-unresponsive prostate cancer in vivo. Male nude mice were injected s.c. with the human androgen-independent prostate tumor DU 145 cells; osmotic minipumps releasing the LHRH agonist Zoladex (LHRH-A) for