Suppression of tumor growth by growth hormone-releasing hormone antagonist JV-1-36 does not involve the inhibition of autocrine production of insulin-like growth factor II in H-69 small cell lung carcinoma

Bombesin/gastrin-releasing peptide antag

Bombesin/gastrin-releasing peptide antagonists RC-3095 and RC-3940-II inhibit tumor growth and decrease the levels and mRNA expression of epidermal growth factor receptors in H-69 small cell lung carcinoma

✍ Miklós Koppán; Gábor Halmos; José M. Arencibia; Najib Lamharzi; Andrew V. Schall 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB 👁 1 views

## BACKGROUND. Antagonists of bombesin/gastrin-releasing peptide (BN/GRP) have been developed to block the autocrine stimulatory effect of BN/GRP on tumors such as small cell lung carcinoma (SCLC). Although several studies have addressed the intracellular events that follow the formation of the re