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[Des-Met14]Bombesin analogues function as small cell lung cancer bombesin receptor antagonists

โœ Scribed by J. Staley; D. Coy; J.E. Taylor; S. Kim; T.W. Moody


Book ID
119142482
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
453 KB
Volume
12
Category
Article
ISSN
0196-9781

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(D-Phe12) bombesin and substance P analo
โœ Zul Merali; Carol A. Merchant; Jacqueline N. Crawley; David H. Coy; Peter Heinz- ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 676 KB

The potency of synthetic bombesin (BN) analogues with D-Phe12 substitutions and substance P analogues was investigated in the rat CNS. (D-Phe12,Leu14)BN, (D-Phe12)BN and (Tyr4,D-Phe12)BN inhibited binding to rat brain slices with IC50 values of approximately 2 microM. Similarly, spantide inhibited b