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Subjective and Objective Risks of Carrying a BRCA1/2 Mutation in Individuals of Ashkenazi Jewish Descent

✍ Scribed by Kimberly Kelly; Howard Leventhal; Deborah Toppmeyer; Judy Much; James Dermody; Monica Marvin; Jill Baran; Marvin Schwalb

Book ID: 110442170
Publisher: Springer
Year: 2003
Tongue: English
Weight: 142 KB
Volume: 12
Category: Article
ISSN: 1059-7700
DOI: 10.1023/a:1023905106360

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## Abstract Germline mutations in the BRCA1 and BRCA2 genes are associated with a significantly increased lifetime risk for developing breast and/or ovarian cancer. However, incomplete penetrance and substantial variability in age of disease onset among carriers of the same mutation suggests the in