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Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families

✍ Scribed by Tonin, P.; Weber, B.; Offit, K.; Couch, F.; Rebbeck, T.R.; Neuhausen, S.; Godwin, A.K.; Daly, M.; Wagner-Costalos, J.; Berman, D.


Book ID
109932177
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
999 KB
Volume
2
Category
Article
ISSN
1078-8956

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A low frequency of non-founder BRCA1 mut
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The 185delAG and 5382insC founder mutations account for the majority of mutations identified in BRCA1 in Ashkenazi Jewish breast and breast-ovarian cancer families. Few non-founder BRCA1 mutations have been identified to date in these families. We initially screened a panel of 245 Ashkenazi Jewish b