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Ashkenazi Jewish population frequencies for common mutations in BRCA1 and BRCA2

✍ Scribed by Roa, Benjamin B.; Boyd, Alfred A.; Volcik, Kelly; Richards, C. Sue

Book ID: 109918300
Publisher: Nature Publishing Group
Year: 1996
Tongue: English
Weight: 330 KB
Volume: 14
Category: Article
ISSN: 1061-4036
DOI: 10.1038/ng1096-185

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BACKGROUND. Families with a high incidence of hereditary breast cancer, and subsequently shown to have terminating mutations in BRCA1 or BRCA2, appear to have a higher incidence of prostate cancer among male relatives. We aimed to determine whether the common germline mutations of BRCA1 or BRCA2 in