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MDM2 SNP309 accelerates breast and ovarian carcinogenesis in BRCA1 and BRCA2 carriers of Jewish–Ashkenazi descent

✍ Scribed by Ronit I. Yarden; Eitan Friedman; Sally Metsuyanim; Tsviya Olender; Edna Ben-Asher; Moshe Zvi Papa

Book ID: 106377684
Publisher: Springer US
Year: 2007
Tongue: English
Weight: 255 KB
Volume: 111
Category: Article
ISSN: 0167-6806
DOI: 10.1007/s10549-007-9797-z

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## Abstract Germline mutations in the BRCA1 and BRCA2 genes are associated with a significantly increased lifetime risk for developing breast and/or ovarian cancer. However, incomplete penetrance and substantial variability in age of disease onset among carriers of the same mutation suggests the in