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Subacute Toxicity of a Purine Nucleoside Phosphorylase Inhibitor in Rats

✍ Scribed by Grushenka H.I. Wolfgang; Michael R. Bleavins; Hussein Hallak; Olajide B. Kasali; Ellen Urda

Book ID
115608526
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
572 KB
Volume
28
Category
Article
ISSN
0272-0590

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## Abstract BCX‐1777, a novel inhibitor of the enzyme purine nucleoside phosphorylase, mimics the charged ribosyl oxocarbenium ion formed during the transition state of the enzyme‐catalyzed Cο£ΏN bond cleavage of nucleosides. BCX‐1777 is a slow‐onset, tight‐binding inhibitor with a __K__~__i__~^\*^ o