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Development of a Practical Synthesis of a Purine Nucleoside Phosphorylase Inhibitor: BCX-4208

✍ Scribed by Kamath, Vivekanand P.; Juarez-Brambila, Jesus J.; Morris, Christopher B.; Winslow, Christopher D.; Morris, Philip E.

Book ID
111987784
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
247 KB
Volume
13
Category
Article
ISSN
1083-6160

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## Abstract BCX‐1777, a novel inhibitor of the enzyme purine nucleoside phosphorylase, mimics the charged ribosyl oxocarbenium ion formed during the transition state of the enzyme‐catalyzed Cο£ΏN bond cleavage of nucleosides. BCX‐1777 is a slow‐onset, tight‐binding inhibitor with a __K__~__i__~^\*^ o